Leukodystrophies

Young child, Neurodegenerative dis with macrocephaly: canavan, Alexander, magelencephalic leukoencephalopathy with subcortical cyst.

Other leukoencephalopathy and macrocephaly: Childhood ataxia with central nervous system hypomylination(CACH)_Megalencephaly, L2 ---Glutaric aciduria, GM2 gangliosidosis

specific clinical features:
.Addison's disease in Adrenoleukodystrophy

hypodontia in Pol-III related or 4H leukodystrophy